Furan- and thiophenecarbothioamide derivatives, their...

C - Chemistry – Metallurgy – 07 – D

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C07D 307/68 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61P 31/18 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2237194

Compounds of formula (I), wherein X is O or S. The compounds of this invention are useful for the inhibition of the replication of Human Immunodeficiency Virus-I (HIV-1) and reverse transcriptase (RT) mutants thereof, in vitro and in vivo. The compounds are useful in the therapeutic or prophylactic treatment of diseases caused by HIV-I and RT mutants thereof, such as acquired immune deficiency syndrome (AIDS).

Cette invention concerne des composés représentés par la formule (I) dans laquelle X est O ou S. Les composés de cette invention s'avèrent utiles pour inhiber la réplication du virus-1 de l'immunodéficience humaine (HIV-1) et des mutants de transcriptase inverse (RT) de ce virus, in vitro et in vivo. Ces composés servent au traitement thérapeutique et prophylactique des maladies provoquées par le virus HIV-1 et par ses mutants RT, telles que le syndrome de l'immunodéficience acquise (SIDA).

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