Furanone derivatives and methods of making same

Details Furanone derivatives and methods of making same Furanone derivatives and methods of making same

C - Chemistry, Metallurgy

07

D

C07D 207/38 (2006.01) A01N 43/08 (2006.01) A01N 43/36 (2006.01) A61K 31/341 (2006.01) A61K 31/4015 (2006.01) A61L 2/16 (2006.01) A61L 12/14 (2006.01) A61P 17/10 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) B08B 17/02 (2006.01) C07D 207/36 (2006.01) C07D 207/44 (2006.01) C07D 307/34 (2006.01) C07D 307/58 (2006.01) C07D 307/60 (2006.01) C07D 307/66 (2006.01) C08F 224/00 (2006.01)

Patent

CA 2495784

Novel synthesis methods, to the products of such novel methods, and to uses of these products. In particular, the present invention provides methods for the reactions of furanones, in particular fimbrolides, with amines. The invention has particular application in the synthesis of halogenated 1,5-dihydro-pyrrol- 2-one, 5-halomethylene substituted 1,5-dihydropyrrol-2-ones (lactam analogues of fimbrolides), 5-amino substituted furanones and 5-aminomethylene-2(5H)- furanones and their synthetic analogues. The invention also relates to novel compounds and uses thereof.

L'invention concerne de nouveaux procédés de synthèse, des produits obtenus par lesdits procédés et les utilisations de ces produits. En particulier, l'invention concerne des procédés permettant de mettre en réaction des furanones, notamment des fimbrolides, avec des amines. L'invention présente une application particulière dans la synthèse de 1,5-dihydro-pyrrol-2-one halogéné, de 1,5-dihydropyrrol-2-ones substitués par 5-halométhylène (analogues de lactame de fimbrolides), de furanones substitués par 5-amino et de 5-aminométhylène-2(5H)-furanones et de leurs analogues synthétiques. L'invention concerne également de nouveaux composés et leurs utilisations.

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