C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/361.1, 260/3
C07D 307/32 (2006.01) C07C 43/166 (2006.01) C07D 303/22 (2006.01) C07D 307/33 (2006.01) C07D 307/58 (2006.01) C07D 307/60 (2006.01) C07D 309/12 (2006.01) C12P 17/04 (2006.01)
Patent
CA 1221929
ABSTRACT OF THE DISCLOSURE Furanone derivatives and their pharma- ceutically acceptable salts have an aldose reductase- inhibitory activity; the new furanone derivatives are represented by the following formula: Image wherein A is a lower alkylene group; R1 is a carboxy, hydroxy, protected hydroxy, lower alkoxycarbornyl, lower alkoxycarbonylamino or lower alkanoyloxy group; R2 is a hydrogen or halogen atom or a halo(lower)- alkyl. group; R3 is a hydrogen or halogen atom; R4 is a hydrogen atom or a hydroxy, carboxy, lower alkoxy, lower alkanoyloxy or lower alkoxycarbonyloxy group and R5 is a hydrogen or halogen atom, or R4 and R5 are taken together to form a group: =CH2; F is a number of double bonds which is equal to 0 or 1; n is an integer of 0 or 1, provided that when F is 0, n is 1 and when F is 1, n is 0.
432395
Imanaka Hiroshi
Kohsaka Masanobu
Okamoto Masanori
Uchida Itsuo
Umehara Kazuyoshi
Fujisawa Pharmaceutical Co. Ltd.
Marcoux & Sher Swabey Mitchell Houle
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