C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/048 (2006.01) A61K 31/4355 (2006.01)
Patent
CA 2575045
The present invention relates to furanopyridine compounds having the general Formula I (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.
La présente invention a trait à des composés de furanopyridine de formule générale (I) et leurs stéréoisomères, tautomères, solvates, sels et dérivés pharmaceutiquement acceptables, et prodrogues. L'invention a également trait à des compositions pharmaceutiques comportant un composé de formule I, à des procédés de modulation d'enzymes Lck et ACK-1 et de traitement de diverses maladies et conditions associées, comprenant l'inflammation, l'inhibition de l'activation des lymphocytes T, la prolifération, l'arthrite, la transplantation d'organes, la lésion ischémique ou de reperfusion répétée, l'infarctus du myocarde, l'accident vasculaire cérébrale, la sclérose en plaques, la maladie intestinale inflammatoire, la maladie de Crohn, le lupus, l'hypersensibilité, le diabète de type 1, le psoriasis, la dermatite, la thyroïdite d'Hashimoto, le syndrome de Sjögren, l'hyperthyroïdisme autoimmun, la maladie d'Addison, les maladies auto-immunes, la glomérulonéphrite, les maladies allergiques, l'asthme, le rhume de foins, l'eczéma, le cancer, le carcinome du côlon, le thymome, entre autres, chez un mammifère, comprenant l'administration au mammifère d'une quantité thérapeutiquement efficace d'un composé de formule I décrit plus haut, et à des procédés de fabrication de médicaments comportant le composé de formule I.
Bemis Jean E.
Fu Jiasheng
Jiao Xianyun
Kayser Frank
Liu Jinqian
Amgen Inc.
Gowling Lafleur Henderson Llp
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