Furanopyrimidines

Details Furanopyrimidines Furanopyrimidines

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/519 (2006.01)

Patent

CA 2571857

The present invention relates to furanopyrimidine compounds having the general Formula (I) and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula (I), methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula (I). The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula (I).

L'invention concerne des composés furanopyrimidine de formule générale (I) et des stéréoisomères, tautomères, solvates, sels et dérivés acceptables sur le plan pharmaceutique, et promédicaments de ceux-ci. L'invention concerne également des compositions pharmaceutiques comprenant un composé de formule (I), des procédés de traitement de maladies et d'états divers chez un mammifère, y compris l'inflammation, l'inhibition de l'activation des lymphocytes T, la prolifération, l'arthrite, la greffe d'organe, les lésions ischémiques ou de reperfusion, l'infarctus du myocarde, les AVC, la sclérose en plaques, la maladie intestinale inflammatoire, la maladie de Crohn, le lupus, l'hypersensibilité, le diabète de type 1, le psoriasis, la dermatite, la thyroïdite de Hashimoto, le syndrome de Sjögren, l'hyperthyroïdie auto-immune, la maladie d'Addison, les maladies auto-immunes, la glomérulonéphrite, les maladies allergiques, l'asthme, le rhume des foins, l'eczéma, le cancer, le carcinome et le thymome du colon. Les procédés de l'invention consistent à administrer au mammifère une dose efficace sur le plan thérapeutique d'un composé de formule (I). L'invention concerne en outre des procédés de production de médicaments, qui comprennent un ou plusieurs composés de formule (I).

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