Furfuryl derivatives of vinblastine-type bisindoles,...

Details Furfuryl derivatives of vinblastine-type bisindoles,... Furfuryl derivatives of vinblastine-type bisindoles,...

C - Chemistry, Metallurgy

07

D

167/209, 260/237

C07D 519/04 (2006.01) A61K 31/475 (2006.01)

Patent

CA 1278791

FURFURYL DERIVATIVES OF VINBLASTINE-TYPE OF BIS- INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME ABSTRACT The invention relates to novel furfuryl derivatives of the general formula (I), (I) Image ( I ) wherein R1 stands for a hydrogen atom or an acetyl group, R2 stands for a hydroxyl or ethyl group of .beta.-position R3 means an ethyl group of .alpha.-position; R4 represents a hydrogen atom; or R3 and R4 together represent an oxygen bridge; and B stands for a hydroxyl or an o-acetyl group, as well as their acid addition salts and pharmaceutical preparations containing these compounds. The invention also relates to a process for preparing these compounds and preparations. The compounds of the general formula (I) show a cytostatic activity with less toxicity than that of the commercially available known vinblastine-type bis-indole alkaloid drugs.

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