Furin inhibitors

Details Furin inhibitors Furin inhibitors

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 31/198 (2006.01) A61K 38/04 (2006.01) A61K 38/08 (2006.01) A61K 38/55 (2006.01) A61P 25/28 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07C 279/14 (2006.01) C07K 5/00 (2006.01) C07K 14/81 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2586086

Inhibitors for the endoprotease furin are provided for the prevention, diagnosis, treatment, and study of human and animal pathologies, which involve furin activity. These pathologies include infections caused by bacteria and virus that exploit host furin activity. These pathologies also include diseases that involve the expression of host proproteins that are processed by furin as a part of growth, development, and maintenance of the host organism including certain cancers of the head and neck.

L'invention concerne des inhibiteurs de l'endoprotéase furine pour la prévention, le diagnostic, le traitement et l'étude de pathologies humaines et animales qui impliquent une activité furine. Lesdites pathologies comptent parmi elles des infections causées par des bactéries et des virus qui exploitent l'activité furine de l'hôte. Lesdites pathologies comprennent aussi des maladies qui impliquent l'expression de proprotéines hôte qui sont transformées par la furine lors de la croissance, du développement et du maintien de l'organisme hôte, y compris dans certains cancers de la tête et du cou.

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