C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/357.3, 260/3
C07D 493/04 (2006.01) C07D 311/18 (2006.01)
Patent
CA 1162929
ABSTRACT OF THE DISCLOSURE: A class of alkyl-substituted angular fluro- coumarins, sometimes termed alkylangelicins, useful in the photochemotherapy of psoriasis and in other skin diseases characterized by cellular hyperproliferation or lack of skin pigmentation is disclosed for topical application or systemic administration. Compared with conventional psoralens the described compounds exhibit a lower risk of skin cancer, absence of phototoxicity problems anderithema to the patient so treated. One preferred compound is 5-methylangelicin.
358489
Baccichetti Francarosa
Bordin Franco
Carlassare Francesco
Dall'acqua Francesco
Fitzpatrick Thomas B.
Consiglio Nazionale Delle Ricerche
Robic Robic & Associes/associates
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