C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/048 (2006.01) A61K 31/4741 (2006.01) A61P 3/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07D 453/02 (2006.01) C07D 491/04 (2006.01) C07D 519/00 (2006.01) C07F 9/6561 (2006.01) C07K 5/06 (2006.01) C12N 1/20 (2006.01) C12N 9/16 (2006.01) C12N 15/00 (2006.01) C12P 17/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2404226
Compounds having the partial structure represented by the following formula (A) or salts thereof which have an excellent phosphodiesterase (PDE) IV inhibitory effect and are useful as preventives and remedies for diseases caused by inflammation, for example, bronchial asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, autoimmune disease and diabetes.
L'invention concerne des composés ayant la structure partielle représentée par leur formule (A) ou leur sel présentant un excellent effet inhibiteur de phosphodiestérase (PDE IV) et sont utiles en tant que préventifs et remèdes contre des maladies provoquées par une inflammation, par exemple, l'asthme, la broncho-pneumopathie chronique obstructive (BPCO), la polyarthrite rhumatoïde, des maladies auto-immunes ainsi que le diabète.
Fujii Nobuhiro
Kawano Yasuhiko
Matsumoto Tatsumi
Tarui Naoki
Uchikawa Osamu
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
Takeda Pharmaceutical Company Limited
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