Furopyridine and furopyrimidine derivatives for the...

C - Chemistry – Metallurgy – 07 – D

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C07D 491/153 (2006.01) A61K 31/4355 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 491/147 (2006.01)

Patent

CA 2491077

This invention relates to a compound of Formula (I) wherein Y is CH or N; Ar1 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each selected independently from (C1-C3)alkoxy halo, OH, CF3, CN, NO2 and (C1- C3)alkyl, said alkyl being optionally substituted with CF3; Ar2 is phenyl or pyridyl each optionally substituted with 1 or 2 substituents each independently selected from halo, OH, CN, NO2, CF3, (C1-C6)alkoxy, NR1R1, S(O)2R2, C(O)R3, and (C1-C6)alkyl optionally substituted with R4, and its use in treating hyper-proliferative disorders.

Cette invention concerne un composé de formule (I), dans laquelle Y désigne CH ou N ; Ar?1¿ représente phényle ou pyridyle chacun éventuellement substitué par 1 ou 2 substituants chacun indépendamment sélectionnés parmi alcoxy (en C¿1?-C¿3?), halo, OH, CF¿3?, CN, NO¿2? et alkyle (en C¿1?-C¿3?), ledit alkyle étant éventuellement substitué par CF¿3? ; Ar?2¿ représente phényle ou pyridyle chacun éventuellement substitué par 1 ou 2 substituants chacun indépendamment sélectionnés parmi halo, OH, CN, NO¿2?, CF¿3?, alcoxy (en C¿1?-C¿6?), NR?1¿R?1¿, S(O)¿2?R?2¿, C(O)R?3¿ et alkyle (en C¿1?-C¿6?) éventuellement substitué par R?4¿. Cette invention concerne également l'utilisation dudit composé dans le traitement de troubles hyperprolifératifs.

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