Furopyridine derivatives and their therapeutical use

Details Furopyridine derivatives and their therapeutical use Furopyridine derivatives and their therapeutical use

C - Chemistry, Metallurgy

07

D

C07D 491/048 (2006.01) A61K 31/44 (2006.01) C07D 221/00 (2006.01) C07D 307/00 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2333629

A compound of formula (i), wherein X and Y are independently CH, N or N-oxide, provided that X and Y do not both represent CH; Z is CO or CS; R1 is alkyl, optionally substituted with one or more halogens; and R2, R3, R4 and R5 are each various organic groups. Such compounds have therapeutic utility, via inhibition of phosphodiesterase IV.

L'invention concerne un composé représenté par la formule (i), dans laquelle X et Y sont indépendamment CH, N ou N-oxyde, à condition que X et Y ne soient pas ensemble CH; Z est CO ou CS; R¿1? est alkyle, éventuellement substitué par un ou plusieurs halogènes; et R¿2?, R¿3?, R¿4? et R¿5? sont chacun divers groupes organiques. Les composés considérés ont une utilité thérapeutique, via une inhibition de la phosphodiéstérase IV.

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