Furopyrimidinedione derivatives as trpa1 modulators

Details Furopyrimidinedione derivatives as trpa1 modulators Furopyrimidinedione derivatives as trpa1 modulators

C - Chemistry, Metallurgy

07

D

C07D 491/048 (2006.01) A61K 31/34 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2756535

The present invention is related to novel furopyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (Formula I) (I)

Cette invention concerne de nouveaux dérivés de furopyrimidinedione à titre de modulateurs de TRPA (sous-famille A du potentiel de récepteurs transitoires). En particulier, les composés ci-décrits sont utiles pour traiter ou prévenir des maladies, des affections et/ou des troubles modulés par TRPAl (sous-famille A du potentiel de récepteurs transitoires, membre 1). Cette invention concerne également des procédés pour préparer les composés ci-décrits, les intermédiaires utilisés pour leur synthèse, des compositions pharmaceutiques les contenant, et des méthodes pour traiter ou prévenir des maladies, des affections et/ou des troubles modulés par TRPAl. (Formule I) (I)

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