Further antiviral pyrimidine nucleosides

Details Further antiviral pyrimidine nucleosides Further antiviral pyrimidine nucleosides

C - Chemistry, Metallurgy

07

H

C07H 19/06 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2067094

2067094 9104982 PCTABS00003 Pyrimidine 4'-thionucleosides of formula (I), where B1 is a pyrimidine base; and either (a) R2 is hydrogen and R3 is hydroxy or fluoro, or (b) R2 is hydroxy and R3 is hydrogen, hydroxy or fluoro, or (c) R2 is fluoro and R3 is hydrogen or hydroxy, or (d) R2 and R3 together form a carbon-carbon bond; and physiologically functional derivatives thereof and processes for their production. Preferably, the base B1 is of formula (II), wherein Y is hydroxy or amino, monoalkylamino or dialkylamino; and X is halogen, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano or nitro. The compounds are useful in the treatment of viral infections.

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