Further improvements relating to drug delivery systems

Details Further improvements relating to drug delivery systems Further improvements relating to drug delivery systems

C - Chemistry, Metallurgy

12

N

167/129, 195/1.1

C12N 11/02 (2006.01) A61K 47/48 (2006.01) C07K 16/30 (2006.01)

Patent

CA 1341383

A three component system, for use in association with one another, in the treatment of malignant diseases comprises: a first component which is a substance or conjugation of substances characterised by (a) one or more molecular configurations that are complementary to molecular configurations associated with malignant cells, such that the first component tends to localise selectively at sites of malignant cells and (b) additionally by one or more catalytic sites; a second component which is able to bind to such part of the first component so as to inactivate the catalytic site of the first component and/or accelerates the clearance of the first component from the blood when the first and second components are administered clinically and a third component which is a substrate for the catalytic site on the first component, one of the end products of the catalysis being a substance which is more cytotoxic to malignant cells than the third component. The use of the second component reduces the extent to which the cytoxic drug is released from the third component in regions of a patients body remote from the target tumour.

616987

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