Further novel alkanophenones

Details Further novel alkanophenones Further novel alkanophenones

C - Chemistry, Metallurgy

07

D

167/207, 260/356

C07D 407/12 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) C07D 311/24 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2025470

4-17747/+ Further novel alkanophenones Abstract Substituted alkanophenones of the general formula Image (I), in which R1 is unsubstituted or fluorinated lower alkyl, R2 is hydrogen, or unsubstituted or fluorinated lower alkyl or lower alkenyl, X is lower alkylene, oxy, thio or a direct bond, alk is lower alkylene, n is 1 or 2, R3 is a 5-membered heteroaryl radical that contains 1 N, O or S atom as hetero atom and is unsubstituted or is substituted by unsubstituted or fluorinated lower alkyl, by etherified or esterified hydroxy, by unsubstituted or lower alkylated amino and/or by free, esterified or amidated carboxy, R4 is free, esterified or amidated carboxy or 5-tetrazolyl, and R5 is hydrogen or lower alkyl, have leucotriene- antagonistic properties and can be used as antiallergic active ingredients in medicaments. The process for their preparation comprises reacting an epoxide of formula II Image (II), in which R1, R2, X, alk, n and R3 are as defined above, with a thiol of formula III Image (III), in which R4 and R5 are as devined above, or with a salt thereof, and, if desired, converting a compound obtainable in accordance with the process into a different compound of formula I, separating a stereoisomeric mixture obtainable in accordance with the process into its components and/or converting a free compound obtainable in accordance with the process into a salt, or a salt obtainable in accordance with the process into the free compound or into a different salt.

Affiliated with

Also associated with

Rating

Further novel alkanophenones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Further novel alkanophenones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Further novel alkanophenones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1617693