Further pro polypeptides and sequences thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2339043

Membrane-bound proteins and receptor molecules have various industrial applications, including as pharmaceutical and diagnostic agents. Receptor immunoadhesins, for instance, can be employed as therapeutic agents to block receptor-ligand interactions. The membrane-bound proteins can also be employed for screening of potential peptide or small molecule inhibitors of the relevant receptor/ligand interaction. Efforts are being undertaken by both industry and academia to identify new, native receptor or membrane-bound proteins. Many efforts are focused on the screening of mammalian recombinant DNA libraries to identifiy the coding sequences for novel receptor or membrane- bound proteins. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Les protéines membranaires et les molécules de récepteur possèdent différentes applications industrielles ; elles peuvent notamment servir d'agent pharmaceutique et d'agent diagnostique. Les immunoadhésines récepteurs, par exemple, peuvent servir d'agents thérapeutiques afin de bloquer les interactions récepteur-ligand. Les protéines membranaires peuvent également servir à cribler de potentiels inhibiteurs peptidiques ou inhibiteurs de petites molécules de l'interaction récepteur-ligand pertinente. Des recherches sont menées dans les domaines industriel et universitaire afin d'identifier de nouvelles protéines natives de récepteur ou membranaires. Nombre de ces recherches se concentrent sur le criblage des bibliothèques d'ADN recombinant de mammifère afin d'identifier les séquences de codage pour de nouvelles protéines de récepteur ou membranaires. L'invention concerne de nouveaux polypeptides et des molécules d'acide nucléique codant pour ces polypeptides. L'invention concerne également des vecteurs et des cellules hôtes contenant lesdites séquences d'acide nucléique, des molécules de polypeptides chimères contenant les polypeptides selon l'invention fusionnées à des séquences de polypeptides hétérologues, des anticorps qui se lient aux polypeptides selon l'invention ainsi que des méthodes de production de ces polypeptides.

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