Further pyrimidine derivatives and their preparation

Details Further pyrimidine derivatives and their preparation Further pyrimidine derivatives and their preparation

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/505 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2148477

There are disclosed N-(fluoroalkoxyphenyl)-2-pyrimidine-amine derivatives of formula (I) wherein R1 is 4-pyridyl, N-oxido-4-pyridyl, 3-indolyl, isoquinolinyl, thienyl or 1H-pyrrolyl, and R2 is fluoro-substituted alkoxy containing up to 2 carbon atoms. These compounds can be used, inter alia, for the therapy of tumoral diseases.

L'invention se rapporte à des dérivés N-(fluoroalcoxyphényl)-2-pyrimidine-amine de formule (I) dans laquelle R¿1? est 4-pyridyle, N-oxydo-4-pyridyle, 3-indolyle, isoquinolinyle, thiényle ou 1H-pyrrolyle, et R¿2? est alcoxy substitué par fluoro, contenant jusqu'à 2 atomes de carbone. On peut utiliser ces composés, entre autres, dans la thérapie des affections tumorales.

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