Fused 1,2,4-thiadiazine derivatives, their preparation and use

Details Fused 1,2,4-thiadiazine derivatives, their preparation and use Fused 1,2,4-thiadiazine derivatives, their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/54 (2006.01)

Patent

CA 2294830

1,2,4-Thiadiazine and 1,4-thiazine derivates represented by formula (I) wherein A, B, D, R1, R2, R3 and R4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system.

L'invention concerne des dérivés de 1,2,4-thiadiazine et de 1,4-thiazine représentés par la formule (I), dans laquelle A, B, D, R?1¿, R?2¿, R?3¿ et R?4¿ sont tels que définis dans le descriptif. L'invention concerne en outre des compositions de ces dérivés et des procédés de préparation des composés. Les composés sont utiles dans le traitement de maladies du système nerveux central, l'appareil cardio-vasculaire, le système pulmonaire, l'appareil digestif et le système endocrinien.

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