C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 9/00 (2006.01) A61P 15/08 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 473/06 (2006.01) C07D 473/16 (2006.01) C07D 473/18 (2006.01) C07D 473/24 (2006.01) C07D 473/34 (2006.01) C07D 473/40 (2006.01) C07D 4
Patent
CA 2507763
A novel compound having excellent DPPIV inhibitory activity. It is a compound represented by the general formula (I) (wherein T1 means an optionally substituted, mono- or bicyclic, 4- to 12-membered heterocycle containing one or two nitrogen atoms therein; the structure shown by (II) means a double bond or single bond; X3 means oxygen or sulfur; X1 means optionally substituted C2- 6 alkynyl, etc.; Z1 means nitrogen or -CR3=; Z2 and Z3 each independently means nitrogen, -CR1=, carbonyl, or -NR2-; and R1, R2, R3, and X2 each independently means optionally substituted C1-6 alkyl, etc.), a salt thereof, or a hydrate of either.
La présente invention concerne un composé possédant une excellente activité inhibitrice DPPIV. Ce composé est représenté par la formule générale (I). Dans cette formule T?1¿ est un hétérocycle ramifié en 4 à 12, monocyclique ou bicyclique éventuellement substitué contenant un ou deux atomes d'azote; la structure représentée par (II) est une double liaison ou une liaison simple; X?3¿ est oxygène ou soufre; X?1¿ est C¿2-6? alkynyle éventuellement substitué, etc.; Z?1¿ est azote ou -CR?3¿=; Z?2¿ et Z?3¿ sont chacun indépendamment azote, -CR?1¿=, carbonyle, ou -NR?2¿-; et R?1¿, R?2¿, R?3¿, et X?2¿ sont chacun indépendamment C¿1-6? alkyle éventuellement substitué, etc.), un sel de celui-ci ou un hydrate de l'autre.
Clark Richard
Kira Kazunobu
Uehara Taisuke
Yoshikawa Seiji
Eisai Co. Ltd.
Eisai R&d Management Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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