C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/4375 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2619111
The present invention is directed to novel substituted fused aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
La présente invention porte sur de nouvelles aminopipéridines fusionnées substituées qui sont des inhibiteurs de l'enzyme dipeptidyl peptidase-IV ("inhibiteurs de DPP-IV") et qui sont utilisées dans le traitement ou la prévention de maladies dans lesquelles l'enzyme dipeptidyl peptidase-IV est impliquée, telles que le diabète et en particulier le diabète de type 2. Cette invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions pour prévenir ou traiter les maladies dans lesquelles l'enzyme dipeptidyl peptidase-IV est impliquée.
Cox Jason M.
Edmondson Scott D.
Mastracchio Anthony
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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