Fused-aryl and heteroaryl derivatives and methods of their use

Details Fused-aryl and heteroaryl derivatives and methods of their use Fused-aryl and heteroaryl derivatives and methods of their use

A - Human Necessities

61

K

A61K 31/496 (2006.01) C07D 241/04 (2006.01) C07D 295/092 (2006.01)

Patent

CA 2549733

The present invention is directed to fused-aryl and heteroaryl derivatives of formula I, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibrornyalgia, pain, diabetic neuropathy, and combinations thereof. FORMULA

L'invention concerne des dérivés hétéroaryle et aryle fusionné de formule (I), des compositions contenant ces dérivés, ainsi que des méthodes d'utilisation de ces compositions dans la prévention et le traitement d'états améliorés par la recapture des monoamines, entre autres les symptômes vasomoteurs, la dysfonction sexuelle, les troubles gastro-intestinaux et génito-urinaires, le syndrome de fatigue chronique, le syndrome de fibromyalgie, les troubles du système nerveux, et des combinaisons de ces états. Les dérivés selon l'invention sont utilisés en particulier pour prévenir ou traiter les états choisis dans le groupe constitué par le trouble dépressif majeur, les symptômes vasomoteurs, le stress et l'incontinence urinaire impérieuse, la fibromyalgie, la douleur, la neuropathie diabétique, et des combinaisons de ces états.

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