Fused benzeneoxyacetic acid derivatives

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 235/40 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/395 (2006.01) C07C 69/712 (2006.01) C07C 233/22 (2006.01) C07C 233/51 (2006.01) C07C 235/34 (2006.01) C07C 235/38 (2006.01) C07C 237/08 (2006.01) C07C 237/20 (2006.01) C07C 243/24 (2006.01) C07C 243/32 (2006.01) C07C 243/36 (2006.01) C07C 251/86 (2006.01) C07C 259/06 (2006.01) C07C 259/08 (2006.01) C07C 275/24 (2006.01) C07C 281/06 (2006.01) C07C 281/10 (2006.01) C07C 281/18 (2006.01) C07C 335/12 (2006.01) C07D 207/337 (2006.01) C07D

Patent

CA 2082566

ABSTRACT A fused benzeneoxyacetic acid derivative of the formula (I): Image (I) (where Image (i) Image , (ii) Image , (iii) Image or (iv) Image ; A is -COW, -NR4-Y or-Z-NR4-CONR2R3; W is -NR2R3, -NR4-OR5, -NR4-NR2R3 or-NR4-N=CR2R3; Y is-CO-R5,-CO-U-NR2R3 or-CS-U-NR2R3; Z is -CH=N- or-CH2-NR6-; R1 is H or alkyl; R2 or R3 is H, (benzoyl)phenyl or R5; 123 R5 is phenyl, hetero ring containing N atom or alkyl substituted by hetero ring containing one N atom or phenyl; R4 or R6 is H, alkyl or (substituent)phenyl; U is bond or alkylene; e is 3-5; f is 1 -3; p or r is 0-4; q is 0-2; s is 0-3) and salts thereof possess an agonistic on PGI2 receptor, so it is useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertention. 124

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