Fused benzeneoxyacetic acid derivatives

Details Fused benzeneoxyacetic acid derivatives Fused benzeneoxyacetic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 251/32 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01) C07C 59/72 (2006.01) C07C 69/712 (2006.01) C07C 239/20 (2006.01) C07C 251/40 (2006.01) C07C 251/42 (2006.01) C07C 251/48 (2006.01) C07C 251/52 (2006.01) C07C 251/54 (2006.01) C07D 207/337 (2006.01) C07D 213/55 (2006.01) C07D 223/04 (2006.01)

Patent

CA 2073917

ABSTRACT A fused benzeneoxyacetic acid derivative of the formula: Image (I) wherein Image is (i) Image (ii) Image (iii) Image or (iv) Image A is (i) Image or (ii) Image 66 R1 is hydrogen or C1-4 alkyl; R2 is hydrogen, C1-6 alkyl or phenyl; R3 is (i) C1-15 alkyl, (ii) C1-8 alkyl substituted by one or two of benzene, C4-7 cycloalkane or 4-7 ring-membered monocyclic ring which contains one nitrogen atom or (iii) C10-15 condensed tricyclic ring; e is 3-5; f is 1-3; p is 0-4; q is 0-2; s is 0-3 With the proviso that, ring(s) in R3 may be substituted by one to three of C1-4 alkyl, 1-4 alkoxy, halogen atom, nitro or trihalomethyl. And, when D ? 8 is the formula (iii) or (iv), -(CH2)p- or =CH-(CH2)s- is attached at the position of a or b on the ring. and non-toxic salts thereof possess an antagonistic activity on PGl2 receptor, so it is useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension. 67

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