Fused bicyclic pyrimidines

Details Fused bicyclic pyrimidines Fused bicyclic pyrimidines

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2694058

Compounds of formula (I), a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.

L'invention porte sur des composés de la formule (I), sur un tautomère ou un stéréoisomère de ces derniers, ou sur un sel de ces derniers, dans laquelle le cycle B et la pyrimidine avec laquelle il est condensé, R4, R5, R6 et R7 sont tels que définis dans la description et les revendications, lesquels composés sont des inhibiteurs efficaces de la voie Pi3K/Akt.

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