Fused bicycloheterocycle substituted quinuclidine derivatives

Details Fused bicycloheterocycle substituted quinuclidine derivatives Fused bicycloheterocycle substituted quinuclidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2551486

Compounds of formula (I) wherein n is 0, 1, or 2; A is N or N+-O-; X is O, S, - NH-, and -N-alkyl-; Ar1 is a 6-membered aromatic ring; and Ar2 is a fused bicycloheterocycle. The compounds are useful in treating conditions or disorders prevented by or ameliorated by a7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

La présente invention décrit des composés de formule (I) selon laquelle n est égal à 0, 1 ou 2 ; A représente N ou N+-O- ; X représente O, S, -NH- ou -N-alkyl- ; Ar1 est un cycle aromatique à six chaînons ; et Ar2 est un bicyclohétérocycle condensé. Lesdits composés peuvent être employés dans le traitement d'états pathologiques ou de troubles inhibés ou soulagés par les ligands de a7 nAChR. La présente invention décrit également des préparations pharmaceutiques incluant des composés de formule (I) ainsi que des méthodes permettant d'employer de tels composés et de telles préparations.

Affiliated with

Also associated with

Rating

Fused bicycloheterocycle substituted quinuclidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fused bicycloheterocycle substituted quinuclidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused bicycloheterocycle substituted quinuclidine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1566079