C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/16 (2006.01) A61K 31/55 (2006.01) A61P 7/00 (2006.01) A61P 35/00 (2006.01) C07D 213/74 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2386799
The invention comprises novel compounds of formula E-B-(Alk)p-Q-(Alk)q-A-G wherein G is a radical of formula (I), (II) or (III) that are effective in the prophylaxis and treatment of diseases, such as integrin receptors mediated diseases, in particular, discuses or conditions mediated by integrin receptors, such as .alpha.,.beta.3, .alpha.,.beta.5, .alpha.,..beta.6, and the like. The invention encompasses novel compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of such diseases and disorders. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
L'invention concerne de nouveaux composés qui sont efficaces dans le cadre de la prophylaxie et du traitement de maladies, tels que des maladies à médiation par récepteurs d'intégrine, notamment des maladies ou conditions médiées par des récepteurs d'intégrine, tels que alpha v beta 3, alpha v beta 5, alpha v beta 6 et similaire. Cette invention concerne des composés nouveaux, des sels correspondants acceptables pharmaceutiquement, des compositions pharmaceutiques et des méthodes destinées à la prophylaxie et au traitement de tels maladies et troubles. Ladite invention a également trait à des procédés d'élaboration de tels composés ainsi qu'à des intermédiaires utilisés dans de tels procédés.
Chen Zhidong
Dominguez Celia
Grenzer-Laber Ellen
Han Nianhe
Liu Longbin
Amgen Inc.
Gowling Lafleur Henderson Llp
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