Fused [d]pyridazin-7-ones

Details Fused [d]pyridazin-7-ones Fused [d]pyridazin-7-ones

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 3/10 (2006.01) A61P 19/08 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2656034

The present invention is directed to fused [d] pyridazin-7-ones of formula (I). The invention is also directed to methods for making and using the fused [d] pyridazin-7-ones. In particular, the compounds of the present invention may he effective in the treatment of diseases or disease states related to the activity of VEGFR2, MLKl and CDK5 enzymes, including, for example, angiogenic disorders and neurodegenerative diseases.

La présente invention concerne des [d] pyridazin-7-ones condensées de la formule (I). L'invention concerne également des procédés de fabrication et d'utilisation des [d] pyridazin-7-ones condensées. Plus spécifiquement, les composés selon l'invention peuvent être efficaces dans le traitement de maladies ou d'états pathologiques associés à l'activité des enzymes VEGFR2, MLKl et CDK5, y compris, notamment, les troubles liés à l'angiogenèse et les maladies neurodégénératives.

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