Fused heterocycle derivative, medicinal composition...

Details Fused heterocycle derivative, medicinal composition... Fused heterocycle derivative, medicinal composition...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/351 (2006.01) A61K 31/381 (2006.01) A61K 31/404 (2006.01) A61K 45/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 7/10 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 19/06 (2006.01) A61P 43/00 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2557269

A fused heterocycle derivative represented by the following general formula (I), a pharmacologically acceptable salt thereof, or a prodrug of either [in the formula, R1 to R4 each is hydrogen, OH, amino, etc.;R5 and R6 each is hydrogen, OH, halogeno, optionally substituted alkyl, etc.; Q is alkylene, alkenylene, etc.; ring A is aryl or heteroaryl; the ring (R1) shown below is any of the rings (R2) shown below; and G is a group represented by the following general formula (G-1) or (G-2) (wherein E1 is hydrogen, fluorine, or OH; and E2 is hydrogen, fluorine, methyl, etc.)]. They have human SGLT inhibitory activity and are useful as a preventive or therapeutic agent for diseases attributable to hyperglycemia, such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, complications of diabetes, and obesity.

Dérivé hétérocyclique fondu représenté par la formule générale suivante (I), un sel pharmaceutiquement acceptable, ou un promédicament de l'un ou l'autre [dans la formule, R?1¿ à R?4¿ sont chacun de l'hydrogène, OH, aminé, etc.;R?5¿ etR?6¿ sont chacun de l'hydrogène, OH, halogène, en option de l'alkyle substitué alkyl, etc.; Q est de l'alkylène, l'alkénylène, etc.; l'anneau A est de l'aryle ou de l'hétéroaryle; l'anneau (R1) montré ci-dessous et l'un des anneaux (R2) montrés ci-dessous; et G est un groupe représenté par la formule générale suivante (G-1) ou (G-2) (où E?1¿ est de l'hydrogène, le fluor, ou OH; et E?2¿ est de l'hydrogène, du fluor, du méthyle, etc.)]. Ils on tune activité inhibitrices SGLT et sont utiles comme agent préventif o thérapeutique pour les maladies attribuables à l'hyperglycémie, telles que le diabète, l'hyperglycémie postprandiale, la tolérance au glucose perturbée, des complications de diabètes et d'obésité.

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