C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/41 (2006.01) C07D 231/56 (2006.01) C07D 235/14 (2006.01) C07D 235/18 (2006.01) C07D 401/12 (2006.01) C07D 407/06 (2006.01) C07D 407/12 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2599987
Provided herein are novel sirtuin-modulating compounds of formula (I) and methods of use thereof . The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, chemo therapeutic induced neuropathy, neuropathy associated with an ischemic event, polyglutamine diseases, ocular diseases and/or -disorders, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
L~invention concerne de nouveaux composés modulateurs de sirtuine de la formule (I) et des procédés d~utilisation idoines. Les composés modulateurs de sirtuine peuvent servir à augmenter la durée de vie d~une cellule, et à traiter et/ou prévenir toute une variété de maladies et de troubles comme, par exemple, les maladies ou les troubles liés au vieillissement et au stress, le diabète, l~obésité, les maladies neurodégénératives, la neuropathie induite par une chimiothérapie, la neuropathie associée à un événement ischémique, les maladies polyglutamines, les maladies et/ou les troubles oculaires, les maladies cardiovasculaires, les troubles de type caillots sanguins, les inflammations, le cancer, et/ou les rougeurs. Elle concerne également les compositions comprenant un composé modulateur de sirtuine en combinaison avec un autre agent thérapeutique.
Bemis Jean
Milburn Michael
Milne Jill
Normington Karl D.
Nunes Joseph J.
Borden Ladner Gervais Llp
Sirtris Pharmaceuticals Inc.
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