Fused heterocyclic compounds useful as kinase modulators

Details Fused heterocyclic compounds useful as kinase modulators Fused heterocyclic compounds useful as kinase modulators

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2623369

Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, and hydrates, thereof, (I) are useful as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, and Z is N or CR3, and R1, R2, R3, X and Y are as defined herein.

L'invention concerne des composés représentés par la formule (I), et des énantiomères, et des diastéréomères, des sels pharmaceutiquement acceptables, et des hydrates de ceux-ci, utilisés comme modulateurs des kinases, notamment pour la modulation de MK2. L'un de E et F représente un atome d'azote, et l'autre représente un atome de carbone, Z représente N ou CR3, et R1, R2, R3, X et Y sont tels que définis dans le descriptif.

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