Fused heterocyclic derivative and use thereof

Details Fused heterocyclic derivative and use thereof Fused heterocyclic derivative and use thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4355 (2006.01) A61K 31/4365 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2716773

The present invention provides a compound having a superior Smo inhibitory activity and lower toxicity, which is sufficiently satisfactory as a pharmaceutical product. The present invention provides a compound represented by the formula (I) wherein ring A is 5- to 7-membered ring optionally having substituent(s), where substituents are optionally bonded to each other to form a ring; X is O, S or NR1 (R1 is a hydrogen atom or a hydrocarbon group optionally having substituent(s)); R2 is carbamoyl optionally having substituent(s); and R3 is hydroxy optionally having substituent(s), or a salt thereof.

Composé doté d'une activité inhibitrice supérieure de la protéine Smoothend (SMO) et une toxicité réduite, et qui sont suffisamment satisfaisant en tant que produit pharmaceutique. L'invention concerne un composé représenté par la formule (I) dans laquelle A représente un anneau de 5 à 7 éléments, avec un ou des substituants éventuellement reliés les uns au autres pour former un motif: X est O, S ou NR1 (R1 est un atome d'hydrogène ou un groupe hydrocarboné comportant éventuellement un ou des substituant(s); R2 est carbamoyle ayant éventuellement un ou des substituant(s) et R3 est un hydroxy ayant éventuellement un ou des substituant(s), ou bien un sel de ces composés.

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