Fused heterocyclic derivative and use thereof

Details Fused heterocyclic derivative and use thereof Fused heterocyclic derivative and use thereof

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2659971

The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.

L'invention concerne un dérivé hétérocyclique fusionné présentant une puissante activité d'inhibition de kinase et son procédé d'utilisation. L'invention concerne un composé de formule (I). Dans cette formule, chaque symbole est tel qu'il est défini dans la description, à l'exception d'un composé particulier. L'invention concerne un sel du dérivé susmentionné et un agent pharmaceutique contenant ce composé ou un promédicament de celui-ci qui est un inhibiteur de kinase (VEGFR, VEGFR2, PDGFR, Raf), un inhibiteur d'angiogenèse, un agent de prophylaxie ou de traitement du cancer, un inhibiteur de croissance ou un suppresseur de métastases cancéreuses.

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