Fused heterocyclic derivative, medicinal composition...

C - Chemistry – Metallurgy – 07 – H

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C07H 15/203 (2006.01) A61K 31/7036 (2006.01) A61K 31/7042 (2006.01) A61K 31/7048 (2006.01) A61K 31/7056 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 7/10 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 19/06 (2006.01) A61P 43/00 (2006.01) C07H 17/00 (2006.01) C07H 17/02 (2006.01) C07H 17/04 (2006.01)

Patent

CA 2520436

A fused heterocyclic derivative represented by the general formula (I) (wherein R1 is hydrogen, OH, etc.; R2 is hydrogen, halogeno, or alkyl; R3 and R4 each is hydrogen, OH, halogeno, etc.; Q is alkylene, etc.; ring A is aryl or heteroaryl; and G is the group represented by the formula (G1) or (G2)), (G1) (G2) a pharmacologically acceptable salt of the derivative, or a prodrug of either. They have excellent inhibitory activity against human SGLT and are useful as preventive or therapeutic agents for diseases attributable to hyperglycemia, such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, complications of diabetes, and obesity.

L'invention concerne un dérivé hétérocyclique fusionné représenté par la formule générale (I). Dans la formule (I), R?1¿ représente hydrogène, OH, etc. ; R?2¿ représente hydrogène, halogéno, ou alkyle ; R?3¿ et R?4¿ représentent chacun hydrogène, OH, halogéno, etc. ; Q représente alkylène, etc. ; le cycle A représente aryle ou hétéroaryle ; et G représente le groupe représenté par la formule (G1) ou (G2), un sel pharmaceutiquement acceptable du dérivé, ou un promédicament de ce dernier. Lesdits éléments présentent une excellente activité inhibitrice dirigée contre les SGLT humains et sont utiles en tant qu'agents préventifs ou thérapeutiques destinés au traitement de maladies liées à l'hyperglycémie, telles que le diabète, l'hyperglycémie postprandiale, l'intolérance au glucose, les complications liées au diabète ainsi que l'obésité.

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