Fused heterocyclic derivatives as ppar modulators

Details Fused heterocyclic derivatives as ppar modulators Fused heterocyclic derivatives as ppar modulators

C - Chemistry, Metallurgy

07

D

C07D 277/60 (2006.01) A61K 31/404 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61K 31/437 (2006.01) A61P 3/10 (2006.01) A61P 29/00 (2006.01) C07D 209/10 (2006.01) C07D 235/18 (2006.01) C07D 263/57 (2006.01) C07D 277/66 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2509202

The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S. S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; (d) E is C(R3) (R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamidek, sulfonamide and acylsulfonamide; (e) B is selected from the group consisting of S, O, C, and N; (f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.

La présente invention concerne des composés représentés par la formule structurelle I, dans laquelle (a) X est sélectionné dans le groupe constitué d'un lien simple, O, S. S(O)¿2? et N; (b) U est un lieur aliphatique; (c) Y est sélectionné dans le groupe constitué de C, O, S, NH et d'un lien simple; (d) E est C(R3) (R4)A ou A et (i) A est sélectionné du groupe constitué de carboxyle, tétrazole, alkylnitrile C¿1?-C¿6?, carboxamidek, sulfonamide et acylsulfonamide; (e) B est sélectionné dans le groupe constitué de S, O, C, et N; (f) Z est sélectionné dans le groupe constitué de N et C; à condition que si B est C, Z est N.

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