Fused heterocyclic derivatives as ppar modulators

Details Fused heterocyclic derivatives as ppar modulators Fused heterocyclic derivatives as ppar modulators

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4155 (2006.01) A61K 31/423 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/437 (2006.01) A61K 31/55 (2006.01) A61P 3/10 (2006.01) A61P 29/00 (2006.01) C07D 209/10 (2006.01) C07D 235/18 (2006.01) C07D 263/57 (2006.01) C07D 277/60 (2006.01) C07D 277/66 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2510516

The present invention is directed to a method of treatment by modulating a peroxisome proliferator activated receptor by employing a compound of Structural Formula (I). The variables in I are defined herein. Also included are compounds, methods of making compounds, and pharmaceutical compositions. The compounds of the present invention are believed to be effective in treating and preventing Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, atherosclerosis, and other disorders related to Syndrome X and cardiovascular diseases.

L'invention concerne une méthode de traitement par modulation d'un récepteur activé par un proliférateur de péroxysome au moyen d'un composé de formule (I). Les variables présentes dans la formule (I) sont spécifiées dans la description. L'invention concerne également des composés, des procédés de fabrication desdits composés et des compositions pharmaceutiques. Lesdits composés sont efficaces dans le traitement et la prévention du syndrome X, du diabète de type II, de l'hyperglycémie, de l'obésité, de la coagulopathie, de l'hypertension, de l'athérosclérose, et tout autre trouble lié au syndrome X et aux maladies cardio-vasculaires.

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