C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/381 (2006.01) A61K 31/407 (2006.01) A61K 31/4162 (2006.01) A61K 31/429 (2006.01) A61P 25/00 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2659060
This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the treatment and prevention of neurological disorders, such as neuropsychiatric and neurodegenerative diseases, as well as pain, ataxia and convulsion. The compounds of the invention have the general structure wherein Q is a member selected from O, S, CR1 and N, X and Y are members independently selected from CR2, O, S, N and NR3.
La présente invention concerne des inhibiteurs innovants de l'enzyme D-aminoacide-oxydase ainsi que des compositions pharmaceutiques qui comprennent les composés de l'invention. L'invention concerne également des procédés de traitement et de prévention de troubles neurologiques, tels que des maladies neuropsychiatriques et neurodégénératives, de même que de la douleur, de l'ataxie et des convulsions. Les composés selon l'invention présentent la structure générale dans laquelle Q est choisi parmi O, S, CR1 et N, X et Y sont choisis indépendamment parmi CR2, O, S, N et NR3.
Dorsey James M.
Fang Qun Kevin
Foglesong Robert J.
Heffernan Michele L.r.
Hopkins Seth C.
Gowling Lafleur Henderson Llp
Sepracor Inc.
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