Fused heterocyclic inhibitors of phosphodiesterase (pde) 7

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01) A61K 31/00 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61P 19/00 (2006.01) C07D 225/04 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/00 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 473/16 (2006.01) C07D 487/00 (2006.01) C07D 487/04 (2006.01) C07D 491/10 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2443835

Fused heterocylic phosphodiesterase 7 (PDE 7) inhibitors of the following formula (I) wherein R1, R2, R5, Z, J1 and J2 are described herein, and analogs thereof are provided which are useful in treating T-cell mediated diseases.

L'invention concerne des inhibiteurs hétérocycliques fusionnés de phosphodiestérase 7 (PDE 7) représentés par la formule (I), dans laquelle R¿1?, R¿2?, R¿5?, Z, J¿1? et J¿2? sont décrits dans le descriptif. L'invention concerne également des analogues desdits inhibiteurs qui conviennent pour le traitement des maladies induites par les lymphocytes T.

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