C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/47 (2006.01) A61K 31/498 (2006.01) A61K 31/538 (2006.01) A61P 25/00 (2006.01) C07D 215/56 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2741126
The present invention is directed to fused heterocyclic compounds of formula (I): which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
La présente invention concerne des composés hétérocycliques condensés de formule (I) (I) qui sont des modulateurs allostériques positifs de récepteur M1 et qui sont utiles dans le traitement de maladies dans lesquelles le récepteur M1 est impliqué, comme la maladie d'Alzheimer, la schizophrénie, la douleur ou les troubles du sommeil. L'invention concerne également des compositions pharmaceutiques comprenant les composés et l'utilisation des composés et des compositions dans le traitement de maladies médiées par le récepteur M1.
Di Marco Christina Ng
Kuduk Scott D.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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