A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/403 (2006.01) A61K 31/427 (2006.01) C07D 403/06 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2526770
The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase- IV enzyme is involved.
L'invention concerne des dérivés d'indoles fusionnés qui sont des inhibiteurs de l'enzyme dipeptidyle peptidase IV (<= inhibiteursDP-IV >=) et que l'on utilise dans le traitement ou la préventionde maladies impliquant l'enzyme dipeptidyle peptidase IV, par exemple les diabètes et, plus précisément, les diabètes type 2. L'invention concerne également des compositions pharmaceutiques comprenant ces composés ainsi que l'utilisation de ces composés et compositions en matière de prévention ou de traitement de telles maladies impliquant l'enzyme dipeptidyle peptidase IV.
Edmondson Scott D.
Mastracchio Anthony
Parmee Emma R.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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