Fused nitrogen containing heterocycles and compositions...

Details Fused nitrogen containing heterocycles and compositions... Fused nitrogen containing heterocycles and compositions...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2722418

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of us-ing such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Ros, KDR, FMS, C-FMS, FLT3, c-Kit, JAK2, JAK3, Aurora, PDGFR, Lck, TrkA, TrkB, TrkC, IGF-IR, ALK4, ALK5 and ALK or combinations thereof.

L'invention concerne des composés, des compositions pharmaceutiques comprenant de tels composés et des procédés utilisant de tels composés, pour traiter et pour prévenir des maladies ou des troubles associés à une activité de kinase anormale ou dérégulée, en particulier, la kinase étant sélectionnée parmi: Ros, KDR, FMS, c-FMS, FLT3, c-Kit, JAK2, JAK3, Aurora, PDGFR, Lck, TrkA, TrkB, TrkC, IGF-1R, ALK4, ALK5 et ALK, ou parmi des combinaisons de celles-ci.

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