Fused or hybrid protein comprising viral antigen and lymphokine

Details Fused or hybrid protein comprising viral antigen and lymphokine Fused or hybrid protein comprising viral antigen and lymphokine

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) C07K 14/035 (2006.01) C07K 14/04 (2006.01) C07K 14/16 (2006.01) C07K 14/52 (2006.01) C07K 14/55 (2006.01) C07K 16/08 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2020668

Disclosed are (1) a fused protein obtained by combining an antigen used for vaccine and a lymphokine by the application of gene engineering, (2) a recombinant DNA containing a nucleotide sequence coding for the above fused protein, (3) a transformant bearing the above recombinant DNA, (4) a method for producing the fused protein which comprises cultivating the above transformant, producing and accumulating the above fused protein in a culture, and collecting the fused protein, and (5) a hybrid protein obtained by chemically combining an antigen used for vaccine with a lymphokine. The resulting fused and hybrid proteins have strong immunogenicity.

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