Fused pentacyclic polyethers

Details Fused pentacyclic polyethers Fused pentacyclic polyethers

C - Chemistry, Metallurgy

07

D

C07D 493/22 (2006.01) A61K 31/35 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2539588

Disclosed are polycyclic polyether compounds of formula: (I) and pharmaceutical compositions comprising such compounds. Wherein R, OR1 and R2 are as defined herein. Also disclosed are methods of regulating mucus clearance in a cell, and methods of treating decreased mucus clearance or mucociliary dysfunction.

Cette invention concerne des composés de polyéther polycyclique représentés par la formule (I) ainsi que des compositions pharmaceutiques renfermant de tels composés. Dans cette formule, R, OR¿1? and R¿2? sont comme définis dans le descriptif. Sont également décrites des méthodes permettant de réguler l'épuration mucociliaire dans une cellule et de traiter une épuration mucociliaire réduite ou un dysfonctionnement mucociliaire.

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