Fused pyrazine compounds

Details Fused pyrazine compounds Fused pyrazine compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/495 (2006.01) A61K 31/4985 (2006.01) C07D 471/04 (2006.01) C07D 487/14 (2006.01) C07D 495/14 (2006.01)

Patent

CA 2310072

Compounds represented by general formula (I) (wherein each symbol is as defined in the description) and salts thereof. The compounds inhibit adhesion molecule expression and are useful for inhibiting various inflammatory diseases, rheumatoid arthritis, allergy, bronchial asthma, atopic dermatitis, psoriasis, ischemic reperfusion injury, nephritis, hepatitis, multiple sclerosis, ulcerative colitis, acute respiratory distress syndrome, graft rejection, sepsis, diabetes and autoimmune diseases, and for preventing and/or remedying sepsis, diabetes, autoimmune disease, cancer metastasis, arteriosclerosis and AIDS.

L'invention concerne des composés représentés par la formule (I) (dans laquelle chaque symbole est défini dans la description) et des sels de ceux-ci. Ces composés inhibent l'expression d'une molécule d'adhésion, et sont utilisés pour inhiber diverses maladies inflammatoires, la polyarthrite rhumatoïdale, l'allergie, l'asthme bronchial, l'eczéma constitutionnel, le psoriasis, les lésions ischémiques consécutives à une reperfusion, la néphrite, l'hépatite, les diverses scléroses, la rectocolite hémorragique, le syndrome de détresse respiratoire aigu, le rejet de greffe, les maladies infectieuses, les diabètes et les maladies auto-immunes. Ces composés empêchent ou remédient aux maladies infectieuses, aux diabètes, aux maladies auto-immunes, aux métastases cancéreuses, à l'artériosclérose et au sida.

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