Fused pyrazine derivatives

Details Fused pyrazine derivatives Fused pyrazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2095444

The present invention is a pyrazine derivative which has glutamate receptor antagonizing activity, represented by formula: (See formula 1) wherein Z represents C or N, provided that two Zs are not N atoms at the same time; R1 represents: (See formula 2) wherein (See formula 3)represents (See formula 4) or (See formula 5), R6 represents H or alkyl, and R7 and R8 represent each H, alkyl, nitro or phenyl, or alternatively R7 and R8 are combined together to represent butadienylene or 1,4-butylene; R2 and R3 represent each H, F, cyano, acyl, nitro, alkyl, morpholino or one of said species of R1; R4 and R5 represent each H, hydroxyl, alkyl, cycloalkyl, heterocycle, phenyl, or Y-substituted alkyl; Y represents hydroxyl, acyloxy, F-substituted methyl, cycloalkyl, tetrahydrofuryl, carboxyl, alkoxycarbonyl or (See formula 6) ; R9 and R10 represent each H or alkyl, or alternatively R9 and R10 are combined together to represent a 5- or 6-membered cyclic group which may contain oxygen atom(s).

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