Fused pyrazolyl compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 497/14 (2006.01) A61K 31/416 (2006.01) C07D 317/70 (2006.01) C07D 491/04 (2006.01) C07D 491/056 (2006.01) C07D 491/14 (2006.01) C07D 497/04 (2006.01)

Patent

CA 2369232

A fused pyrazolyl compound of the following formula: (see above formula) wherein each of Ar1, Ar2, and Ar3, independently, is phenyl, thienyl, pyrrolyl, or furyl, optionally substituted with halo, alkyl, carboxyl, alkoxycarbonyl, thiocarbonyl, aminocarbonyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, or thioalkyl; each of X and Y, independently, is O, S, or NH; m is 1, 2, or 3; and n is 0, 1, 2, 3, or 4. Also disclosed is a pharmaceutical composition containing a pharmaceutically effective amount of the compound described above.

Divulgation d'un composé pyrazolylique fusionné ayant la formule suivante (voir la formule susmentionnée), dans laquelle Ar1, Ar2 et Ar3 sont chacun, indépendamment, un phényle, un thiényle, un pyrrolyle ou un furyle, optionnellement substitué par un halogène, un alkyle, un carboxyle, un alcoxycarbonyle, un thiocarbonyle, un aminocarbonyle, un hydroxyalkyle, un alcoxyalkyle, un aminoalkyle ou un thioalkyle, X et Y sont, indépendamment, O, S ou NH, m est égal à 1, 2 ou 3, n est égal à 0, 1, 2, 3 ou 4. Sont également divulguées une composition pharmaceutique et une quantité pharmaceutiquement efficace du composé divulgué ci-dessus.

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