C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/32 (2006.01) A61K 31/501 (2006.01) A61K 31/502 (2006.01) A61K 31/5025 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61K 31/542 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61K 31/554 (2006.01) A61P 3/10 (2006.01) A61P 7/08 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 13/12 (2006.01) A61P 25/00 (2006.01) A61P 27/06 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2476406
Fused pyridazine derivatives represented by the following general formula (I) (wherein each symbol is as defined in the description) and pharmaceutically acceptable salts thereof: (I) Because of inhibiting poly(ADP- ribose)polymerase, the compounds represented by the general formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer~s disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV, etc.) and sensitizers and immunosuppressants in treating cancer.
La présente invention concerne des dérivés de pyridazine condensés représentés par la formule générale (1) suivante (dans laquelle chaque symbole est tel que défini dans la description) et leurs sels pharmaceutiquement acceptables. Etant donné qu'ils inhibent la poly(ADP-ribose)polymérase, les composés de la formule (1) sont utilisés comme remèdes prophylactiques et/ou curatifs dans diverses maladies ischémiques (du cerveau, du cordon, du coeur, du système digestif, du muscle squelettique, de la rétine, etc.), dans les maladies inflammatoires (maladie intestinale inflammatoire, cérébrosclérose multiple, arthrite, etc.), dans les maladies neurodégénératives (troubles extrapyramidaux, maladie d'Alzheimer, dystrophie musculaire, sténose lombaire, etc.), dans le diabète, l'état de choc, les traumatismes crâniens, l'insuffisance rénale, l'hyperalgésie, etc. Les composés de l'invention sont en outre utilisés comme agents contre les rétrovirus (VIH, etc.) et comme sensibilisateurs et immunosuppresseurs dans les traitements anticancéreux.
Kamanaka Yoshihisa
Kamoshima Wataru
Seko Takuya
Takahashi Shinya
Takeuchi Jun
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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