C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 239/91 (2006.01)
Patent
CA 2572083
Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
L'invention concerne des composés possédant la formule suivante (formule), dans laquelle les variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X et l'indice "n" sont décrits dans l'invention. Les composés faisant l'objet de l'invention sont utiles dans le traitement d'états et de maladies inflammatoires ou immunitaires. L'invention porte aussi sur des compositions et des procédés de traitement utilisant les composés faisant l'objet de l'invention. Par exemple, les procédés faisant l'objet de l'invention sont utiles dans le traitement de troubles ou de maladies immunitaires telles que la sclérose en plaques, l'arthrite rhumatoïde, le psoriasis ou la maladie intestinale inflammatoire.
Bergeron Philippe
Chen Xiaoqi
Deignan Jeffrey
Du Xiaohui
Duquette Jason A.
Amgen Inc.
Amgen Sf Llc
Osler Hoskin & Harcourt Llp
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