Fused pyrimidinedione derivatives as trpa1 modulators

Details Fused pyrimidinedione derivatives as trpa1 modulators Fused pyrimidinedione derivatives as trpa1 modulators

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 13/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2756518

The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or pre-venting diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. Formula (I)

Cette invention concerne de nouveaux dérivés de pyrimidinediones fusionnés de formule (I) qui sont des modulateurs des récepteurs TRPA (Transient Receptor Potential, sous-famille A). L'invention concerne en particulier des composés utilisés pour traiter ou prévenir les maladies, les pathologies et/ou les affections dans lesquelles intervient le récepteur TRPAl (Transient Receptor Potential, sous-famille A, membre 1). Cette invention concerne également des procédés de préparation de composés décrits ici, des intermédiaires utilisés pour leur synthèse, des compositions pharmaceutiques les renfermant et des méthodes de traitement ou de prévention des maladies, des pathologies et/ou des affections dans lesquelles intervient le récepteur TRPAl. Formule (I)

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