Fused pyrimidineone compounds as trpv3 modulators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2720357

The present invention provides transient receptor potential vanilloid (TRPV) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRP V3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.

Cette invention concerne des modulateurs des canaux TRP du type vanilloïde (TRPV). En particulier, les composés ci-décrits sont utiles pour traiter ou prévenir les maladies, les affections et/ou les troubles modulés par les TRP V3. Des procédés de préparation des composés ci-décrits, les intermédiaires utilisés dans leur synthèse, des compositions pharmaceutiques les contenant, et des procédés pour traiter ou prévenir les maladies, les affections et/ou les troubles modulés par les TRPV3 sont également décrits.

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