Fused pyrimidines as akt inhibitors

Details Fused pyrimidines as akt inhibitors Fused pyrimidines as akt inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2752114

The present invention relates to compounds of formula (I), a N-oxide or tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6, R7, R10, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.

La présente invention concerne des composés de formule (I), un N-oxyde ou un tautomère ou un stéréo-isomère de ces composés, ou un sel de ceux-ci, où le cycle B et l'imidazole avec lequel il est condensé, R4, R6, R7, R10, m et n ont les significations telles que données dans la description et les revendications, qui sont des inhibiteurs efficaces de la voie Pi3K/Akt, des procédés pour leur production et leur utilisation en tant qu'agents pharmaceutiques.

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